SARS-CoV-2 Viremia Precedes an IL6 Response in Severe COVID-19 Patients: Results of a Longitudinal Prospective Cohort.

Background: Interleukin 6 (IL6) levels and SARS-CoV-2 viremia have been correlated with COVID-19 severity. The association over time between them has not been assessed in a prospective cohort. Our aim was to evaluate the relationship between SARS-CoV-2 viremia and time evolution of IL6 levels in a COVID-19 prospective cohort. Methods: Secondary analysis from a prospective cohort including COVID-19 hospitalized patients from Hospital Universitario La Princesa between November 2020 and January 2021. Serial plasma samples were collected from admission until discharge. Viral load was quantified by Real-Time Polymerase Chain Reaction and IL6 levels with an enzyme immunoassay. To represent the evolution over time of both variables we used the graphic command twoway of Stata. Results: A total of 57 patients were recruited, with median age of 63 years (IQR [53-81]), 61.4% male and 68.4% Caucasian. The peak of viremia appeared shortly after symptom onset in patients with persistent viremia (more than 1 sample with > 1.3 log10 copies/ml) and also in those with at least one IL6 > 30 pg/ml, followed by a progressive increase in IL6 around 10 days later. Persistent viremia in the first week of hospitalization was associated with higher levels of IL6. Both IL6 and SARS-CoV-2 viral load were higher in males, with a quicker increase with age. Conclusion: In those patients with worse outcomes, an early peak of SARS-CoV-2 viral load precedes an increase in IL6 levels. Monitoring SARS-CoV-2 viral load during the first week after symptom onset may be helpful to predict disease severity in COVID-19 patients.

Relevant SARS-CoV-2 viremia is associated with COVID-19 severity: Prospective cohort study and validation cohort.

Early kinetics of SARS-CoV-2 viral load (VL) in plasma determined by quantitative reverse-transcription polymerase chain reaction (RT-PCR) was evaluated as a predictor of poor clinical outcome in a prospective study and assessed in a retrospective validation cohort. Prospective observational single-center study including consecutive adult patients hospitalized with COVID-19 between November 2020 and January 2021. Serial plasma samples were obtained until discharge. Quantitative RT-PCR was performed to assess SARS-CoV-2 VL. The main outcomes were in-hospital mortality, admission to the Intensive Care Unit (ICU), and their combination (Poor Outcome). Relevant viremia (RV), established in the prospective study, was assessed in a retrospective cohort including hospitalized COVID-19 patients from April 2021 to May 2022, in which plasma samples were collected according to clinical criteria. Prospective cohort: 57 patients were included. RV was defined as at least a twofold increase in VL within ≤2 days or a VL > 300 copies/ml, in the first week. Patients with RV (N = 14; 24.6%) were more likely to die than those without RV (35.7% vs. 0%), needed ICU admission (57% vs. 0%) or had Poor Outcome (71.4% vs. 0%), (p < 0.001 for the three variables). Retrospective cohort: 326 patients were included, 18.7% presented RV. Patients with RV compared with patients without RV had higher rates of ICU-admission (odds ratio [OR]: 5.6 [95% confidence interval [CI]: 2.1-15.1); p = 0.001), mortality (OR: 13.5 [95% CI: 6.3-28.7]; p < 0.0001) and Poor Outcome (OR: 11.2 [95% CI: 5.8-22]; p < 0.0001). Relevant SARS-CoV-2 viremia in the first week of hospitalization was associated with higher in-hospital mortality, ICU admission, and Poor Outcome. Findings observed in the prospective cohort were confirmed in a larger validation cohort.

SARS-CoV-2 Viremia Precedes an IL6 Response in Severe COVID-19 Patients: Results of a Longitudinal Prospective Cohort

Background Interleukin 6 (IL6) levels and SARS-CoV-2 viremia have been correlated with COVID-19 severity. The association over time between them has not been assessed in a prospective cohort. Our aim was to evaluate the relationship between SARS-CoV-2 viremia and time evolution of IL6 levels in a COVID-19 prospective cohort. Methods Secondary analysis from a prospective cohort including COVID-19 hospitalized patients from Hospital Universitario La Princesa between November 2020 and January 2021. Serial plasma samples were collected from admission until discharge. Viral load was quantified by Real-Time Polymerase Chain Reaction and IL6 levels with an enzyme immunoassay. To represent the evolution over time of both variables we used the graphic command twoway of Stata. Results A total of 57 patients were recruited, with median age of 63 years (IQR [53–81]), 61.4% male and 68.4% Caucasian. The peak of viremia appeared shortly after symptom onset in patients with persistent viremia (more than 1 sample with > 1.3 log10 copies/ml) and also in those with at least one IL6 > 30 pg/ml, followed by a progressive increase in IL6 around 10 days later. Persistent viremia in the first week of hospitalization was associated with higher levels of IL6. Both IL6 and SARS-CoV-2 viral load were higher in males, with a quicker increase with age. Conclusion In those patients with worse outcomes, an early peak of SARS-CoV-2 viral load precedes an increase in IL6 levels. Monitoring SARS-CoV-2 viral load during the first week after symptom onset may be helpful to predict disease severity in COVID-19 patients.

Risk and protective factors associated with suicidal behaviour during the COVID-19 pandemic crisis amongst college students in Spain

The COVID-19 pandemic is expected to have increased suicidal behavior. The current study evaluates the patterns, risk and protective factors of suicidal behavior among college students in Spain (N = 517) one year after the start of the COVID-19 pandemic. Anxiety, alcohol use and cannabis use (risk factors), and social support and COVID-19 fear (protective factors), were associated with suicidal behavior. These were relatively high among students (22.8% indicated a suicide risk and 9.7% have planned suicide), making it essential to have suicide prevention strategies for university students during the COVID-19 pandemic. The implications for Social Work are discussed. [ FROM AUTHOR] Copyright of Social Work in Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

COVID-19 Fear, Resilience, Social Support, Anxiety, and Suicide among College Students in Spain.

Worldwide, previous studies have expressed concerns regarding the broad psychological effects of the COVID-19 pandemic among college students as they are considered an especially vulnerable group. However, few studies have examined the prevalence of, risk of, and protective factors associated with fear of COVID-19 among college students in Europe. We have sought to address gaps in the literature by conducting a cross-sectional survey among 517 college students (79.1% women and 20.9% men) from a public university in the southeast of Spain. Participants were asked to complete the Fear of COVID-19 scale (FCV-19S) questionnaire and answer questions related to resilience, social support, anxiety, and suicide risk levels using validated scales. The results of the analysis of the variables associated with fear of COVID-19 suggest that, in addition to gender, the factor of anxiety shows a robust positive association and effect with COVID-19 fear (p < 0.001). According to our results, university institutions must adopt support mechanisms to alleviate psychological impacts on students during this pandemic, treating it similarly to other disasters. Implications for social work to reduce COVID-19 fear are also discussed.

COVID-19 y comunidad gitana: Enfoques en la prensa española

Durante el Estado de Alarma en España, el Consejo para la Eliminación de la Discriminación Racial o Étnica expresó su preocupación ante los numerosos casos de discriminación, rechazo y odio que se han producido contra la comunidad gitana. Este trabajo tiene como objetivo principal conocer el tratamiento mediático utilizado para dar cobertura a las noticias de prensa que vinculan el COVID-19 con la comunidad gitana en España. La metodología desarrollada es de carácter mixto, utilizando el análisis del discurso y el de contenido como técnicas de investigación. El análisis de datos se realiza con el software ATLAS.ti. Los resultados principales reflejan que las atribuciones estereotipadas de la comunidad gitana, como un exogrupo con bajo estatus social, precario, conflictivo, delincuencial y peligroso, se han intensificado en el contexto del COVID-19. Por otra parte, se han evidenciado nuevas atribuciones que representan a la comunidad gitana como "transmisores del COVID-19", reforzando una imagen como población que atenta contra la salud pública del país. Se concluye alertando que las representaciones sociales de la comunidad gitana en la prensa española favorecen la (re)producción de escenarios de conflictividad, estigmatización y rechazo.Alternate abstract:During the State of Alarm in Spain, the Council for the Elimination of Racial or Ethnic Discrimination expressed its concern about the numerous cases of discrimination, rejection and hatred that have occurred against the Gypsy Community. This work has as main objective to know the media treatment used to give coverage to the press news that link the COVID-19 with the Gypsy Community in Spain. The methodology developed is of a mixed nature, using discourse analysis and content analysis as research techniques. The data analysis is carried out with the software ATLAS.ti. The main results reflect that the stereotyped attributes of the Gypsy Community, as an exogroup with low social status, precarious, conflictive, criminal and dangerous, have been intensified in the context of the COVID-19. On the other hand, new attributions have become evident that represent the Gypsy Community as "transmitters of the COVID-19", reinforcing an image as a population that threatens the public health of the country. It concludes by warning that the social representations of the Gypsy Community in the Spanish press favour the (re)production of scenarios of conflict, stigmatization and rejection.